HIV infection, antiretroviral therapy, and measures of endothelial function, inflammation, metabolism, and oxidative stress.

ABSTRACT:

Background

HIV-infected patients have an increased risk of cardiovascular disease (CVD). Impaired endothelial function is an early risk factor for CVD in the general population. It is presumed that HIV infection is associated with impaired endothelial function, but results have been inconsistent.

Objectives

Our objectives were to determine the relationships between HIV infection, virologic suppression with antiretroviral therapy (ART), in vivo measures of conduit artery and microvascular endothelial function, and circulating biomarkers of pathways associated with CVD.

Methods

We performed a cross-sectional analysis of three prospectively enrolled groups from a single center: 28 were HIV-infected and virologically-suppressed on a regimen of FTC/TDF/EFV (HIV+ART+), 44 w

SUBMITTER: Dysangco A 

PROVIDER: S-EPMC5560712 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature