Early-Age Running Enhances Activity of Adult-Born Dentate Granule Neurons Following Learning in Rats.

ABSTRACT: Cognitive reserve, the brain's capacity to draw on enriching experiences during youth, is believed to protect against memory loss associated with a decline in hippocampal function, as seen in normal aging and neurodegenerative disease. Adult neurogenesis has been suggested as a specific mechanism involved in cognitive (or neurogenic) reserve. The first objective of this study was to compare learning-related neuronal activity in adult-born versus developmentally born hippocampal neurons in juvenile male rats that had engaged in extensive running activity during early development or reared in a standard laboratory environment. The second objective was to investigate the long-term effect of exercise in rats on learning and memory of a contextual fear (CF) response later in adulthood. These ai

SUBMITTER: Shevtsova O 

PROVIDER: S-EPMC5560743 | biostudies-literature | 2017 Jul-Aug

REPOSITORIES: biostudies-literature