Synaptotagmin isoforms confer distinct activation kinetics and dynamics to chromaffin cell granules.

ABSTRACT: Adrenomedullary chromaffin cells respond to sympathetic nervous system activation by secreting a cocktail of potent neuropeptides and hormones into the circulation. The distinct phases of the chromaffin cell secretory response have been attributed to the progressive fusion of distinct populations of dense core granules with different activation kinetics. However, it has been difficult to define what distinguishes these populations at the molecular level. Functional segregation of granule pools may depend on selective sorting of synaptotagmin-1 (Syt-1) and synaptotagmin-7 (Syt-7), which our previous work showed are rarely cosorted to the same granule. Here we assess the consequences of selective sorting of Syt isoforms in chromaffin cells, particularly with respect to granule dynamics and a

SUBMITTER: Rao TC 

PROVIDER: S-EPMC5560776 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature