Genetics of Genome-Wide Recombination Rate Evolution in Mice from an Isolated Island.

ABSTRACT: Recombination rate is a heritable quantitative trait that evolves despite the fundamentally conserved role that recombination plays in meiosis. Differences in recombination rate can alter the landscape of the genome and the genetic diversity of populations. Yet our understanding of the genetic basis of recombination rate evolution in nature remains limited. We used wild house mice (Mus musculus domesticus) from Gough Island (GI), which diverged recently from their mainland counterparts, to characterize the genetics of recombination rate evolution. We quantified genome-wide autosomal recombination rates by immunofluorescence cytology in spermatocytes from 240 F₂ males generated from intercrosses between GI-derived mice and the wild-derived inbred strain WSB/EiJ. We identif

SUBMITTER: Wang RJ 

PROVIDER: S-EPMC5560792 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature