Identification of the Consistently Altered Metabolic Targets in Human Hepatocellular Carcinoma.

ABSTRACT:

Background & aims

Cancer cells rely on metabolic alterations to enhance proliferation and survival. Metabolic gene alterations that repeatedly occur in liver cancer are largely unknown. We aimed to identify metabolic genes that are consistently deregulated, and are of potential clinical significance in human hepatocellular carcinoma (HCC).

Methods

We studied the expression of 2,761 metabolic genes in 8 microarray datasets comprising 521 human HCC tissues. Genes exclusively up-regulated or down-regulated in 6 or more datasets were defined as consistently deregulated. The consistent genes that correlated with tumor progression markers (ECM2 and MMP9) (Pearson correlation P < .05) were used for Kaplan-Meier overall survival analysis in a patient cohort. We

SUBMITTER: Nwosu ZC 

PROVIDER: S-EPMC5560912 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature