Magnetic resonance imaging study of eye congenital birth defects in mouse model.

ABSTRACT:

Purpose

Embryonic eyelid closure is a well-documented morphogenetic episode in mammalian eye development. Detection of eyelid closure defect in humans is a major challenge because eyelid closure and reopen occur entirely in utero. As a consequence, congenital eye defects that are associated with failure of embryonic eyelid closure remain unknown. To fill the gap, we developed a mouse model of defective eyelid closure. This preliminary work demonstrates that the magnetic resonance imaging (MRI) approach can be used for the detection of extraocular muscle abnormalities in the mouse model.

Methods

Mice with either normal (Map3k1^+/- ) or defective (Map3k1^-/- ) embryonic eyelid closure were used in this study. Images of the extraocular muscles

SUBMITTER: Lee JH 

PROVIDER: S-EPMC5561137 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature