The association of childhood maltreatment with depression and anxiety is not moderated by the oxytocin receptor gene.

ABSTRACT:

Background

The oxytocin receptor (OXTR) gene may be involved in resilience or vulnerability towards stress, and hence in the development of stress-related disorders. There are indications that OXTR single nucleotide polymorphisms (SNPs) interact with early life stressors in predicting levels of depression and anxiety. To replicate and extend these findings, we examined whether three literature-based OXTR SNPs (rs2254298, rs53576, rs2268498) interact with childhood maltreatment in the development of clinically diagnosed depression and anxiety disorders.

Methods

We included 2567 individuals from the Netherlands Study of Depression and Anxiety. This sample consisted of 387 healthy controls, 428 people with a current or past depressive disorder, 243 people with a current or past

SUBMITTER: Tollenaar MS 

PROVIDER: S-EPMC5561157 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature