Microcephalic Osteodysplastic Primordial Dwarfism, Type II: a Clinical Review.

ABSTRACT:

Purpose of the review

This review will provide an overview of the microcephalic primordial dwarfism (MPD) class of disorders and provide the reader comprehensive clinical review with suggested care guidelines for patients with microcephalic osteodysplastic primordial dwarfism, type II (MOPDII).

Recent findings

Over the last 15 years, significant strides have been made in the diagnosis, natural history, and management of MOPDII. MOPDII is the most common and well described form of MPD. The classic features of the MPD group are severe pre- and postnatal growth retardation, with marked microcephaly. In addition to these features, individuals with MOPDII have characteristic facies, skeletal dysplasia, abnormal dentition, and an increased risk for cerebrovascular disease and insu

SUBMITTER: Bober MB 

PROVIDER: S-EPMC5561166 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature