The Role of Rho-GTPases and actin polymerization during Macrophage Tunneling Nanotube Biogenesis.

ABSTRACT: Macrophage interactions with other cells, either locally or at distances, are imperative in both normal and pathological conditions. While soluble means of communication can transmit signals between different cells, it does not account for all long distance macrophage interactions. Recently described tunneling nanotubes (TNTs) are membranous channels that connect cells together and allow for transfer of signals, vesicles, and organelles. However, very little is known about the mechanism by which these structures are formed. Here we investigated the signaling pathways involved in TNT formation by macrophages using multiple imaging techniques including super-resolution microscopy (3D-SIM) and live-cell imaging including the use of FRET-based Rho GTPase biosensors. We found that formation of

SUBMITTER: Hanna SJ 

PROVIDER: S-EPMC5561213 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature