Dynamic local connectivity uncovers altered brain synchrony during propofol sedation.

ABSTRACT: Human consciousness is considered a result of the synchronous "humming" of multiple dynamic networks. We performed a dynamic functional connectivity analysis using resting state functional magnetic resonance imaging (rsfMRI) in 14 patients before and during a propofol infusion to characterize the sedation-induced alterations in consciousness. A sliding 36-second window was used to derive 59 time points of whole brain integrated local connectivity measurements. Significant changes in the connectivity strength (Z Corr) at various time points were used to measure the connectivity fluctuations during awake and sedated states. Compared with the awake state, sedation was associated with reduced cortical connectivity fluctuations in several areas connected to the default mode network and around t

SUBMITTER: Bharath RD 

PROVIDER: S-EPMC5561230 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature