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DNA repair proteins affect the lifecycle of herpes simplex virus 1.

ABSTRACT: We report that herpes simplex virus 1 (HSV-1) infection can activate and exploit a cellular DNA damage response that aids viral replication in nonneuronal cells. Early in HSV-1 infection, several members of the cellular DNA damage-sensing machinery are activated and accumulate at sites of viral DNA replication. When this cellular response is abrogated, formation of HSV-1 replication centers is retarded, and viral production is compromised. In neurons, HSV-1 replication centers fail to mature, and the DNA damage response is not initiated. These data suggest that the failure of neurons to mount a DNA damage response to HSV-1 may contribute to the establishment of latency.

SUBMITTER: Lilley CE

PROVIDER: S-EPMC556126 | biostudies-literature | 2005 Apr

REPOSITORIES: biostudies-literature

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DNA repair proteins affect the lifecycle of herpes simplex virus 1.

Lilley Caroline E CE Carson Christian T CT Muotri Alysson R AR Gage Fred H FH Weitzman Matthew D MD

Proceedings of the National Academy of Sciences of the United States of America 20050411 16

We report that herpes simplex virus 1 (HSV-1) infection can activate and exploit a cellular DNA damage response that aids viral replication in nonneuronal cells. Early in HSV-1 infection, several members of the cellular DNA damage-sensing machinery are activated and accumulate at sites of viral DNA replication. When this cellular response is abrogated, formation of HSV-1 replication centers is retarded, and viral production is compromised. In neurons, HSV-1 replication centers fail to mature, an ...[more]

PMID: 15824307

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