Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme.

ABSTRACT: Glioblastoma multiforme (GBM) is the most common form of malignant glioma, characterized by genetic instability, intratumoral histopathological variability, and unpredictable clinical behavior. We investigated global gene expression in surgical samples of brain tumors. Gene expression profiling revealed large differences between normal brain samples and tumor tissues and between GBMs and lower-grade oligodendroglial tumors. Extensive differences in gene expression were found among GBMs, particularly in genes involved in angiogenesis, immune cell infiltration, and extracellular matrix remodeling. We found that the gene expression patterns in paired specimens from the same GBM invariably were more closely related to each other than to any other tumor, even when the paired specimens had strik

SUBMITTER: Liang Y 

PROVIDER: S-EPMC556127 | biostudies-literature | 2005 Apr

REPOSITORIES: biostudies-literature