Deficient amygdala-prefrontal intrinsic connectivity after effortful emotion regulation in borderline personality disorder.

ABSTRACT: Emotion instability in borderline personality disorder (BPD) has been associated with an impaired fronto-limbic inhibitory network. However, functional connectivity (FC) underlying altered emotion regulation in BPD has yet to be established. Here, we used resting-state fMRI to investigate enduring effects of effortful emotion regulation on the amygdala intrinsic FC in BPD. In this multicenter study, resting-state fMRI was acquired before and after an emotion regulation task in 48 BPD patients and 39 non-patient comparison individuals. The bilateral amygdalae were used as a seed in the whole-brain FC analysis and two-way mixed ANOVA to test whether BPD patients exhibited weaker post-task increase in the amygdala intrinsic FC with the prefrontal cortex (PFC), compared to non-patients. Subseq

SUBMITTER: Baczkowski BM 

PROVIDER: S-EPMC5561271 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature