Time-limited modulation of appetitive Pavlovian memory by D1 and NMDA receptors in the nucleus accumbens.

ABSTRACT: Recent research has implicated the nucleus accumbens (NAc) in consolidating recently acquired goal-directed appetitive memories, including spatial learning and other instrumental processes. However, an important but unresolved issue is whether this forebrain structure also contributes to the consolidation of fundamental forms of appetitive learning acquired by Pavlovian associative processes. In addition, although dopaminergic and glutamatergic influences in the NAc have been implicated in instrumental learning, it is unclear whether similar mechanisms operate during Pavlovian conditioning. To evaluate these issues, the effects of posttraining intra-NAc infusions of D1, D2, and NMDA receptor antagonists, as well as d-amphetamine, were determined on Pavlovian autoshaping in rats, which asse

SUBMITTER: Dalley JW 

PROVIDER: S-EPMC556132 | biostudies-literature | 2005 Apr

REPOSITORIES: biostudies-literature