Vitamin D supplementation differentially affects seasonal multiple sclerosis disease activity.

ABSTRACT:

Objectives

Low ultraviolet-B (UVB) radiation causes hypovitaminosis D, which is a known risk factor for multiple sclerosis (MS) and associated with MS disease activity. Our objective is to test whether vitamin D supplementation is most effective in lowering disease activity during the period of the year with low UVB radiation and consequently low serum 25-hydroxyvitamin D₃ (25(OH)D₃) concentration.

Methods

Retrospective analysis of medical records from our outpatient department identified 40 MS patients with available data of at least 6 months before and during oral vitamin D supplementation. Serum 25(OH)D₃ concentration was analyzed using immunoassay. UVB radiation data were provided by the local government. Annualized and quarterly relapse

SUBMITTER: Miclea A 

PROVIDER: S-EPMC5561321 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature