Longitudinal Changes in Brain Metabolic Activity after Withdrawal from Escalation of Cocaine Self-Administration.

ABSTRACT: The chronic and relapsing nature of addiction suggests that drugs produce persistent adaptations in the brain that make individuals with drug addiction particularly sensitive to drug-related cues and stress and incapable of controlling drug-seeking and drug-taking behavior. In animal models, several long-lasting neuroadaptations have been described. However, few studies have used brain-imaging techniques to provide a complete picture of brain functioning in the course of withdrawal from cocaine. In this study, we allowed rats to self-administer cocaine under short-access (1-h/day) or long-access (6-h/day) conditions and used 2-deoxy-2-(¹⁸F)fluoro-d-glucose (¹⁸FDG) positron emission tomography scanning to investigate the longitudinal changes in metabolic activity 1 and

SUBMITTER: Nicolas C 

PROVIDER: S-EPMC5561337 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature