Serious adverse events and the risk of stroke in patients with rheumatoid arthritis: results from the German RABBIT cohort.

ABSTRACT:

Objective

In the general population, the incidence of stroke is increased following other serious events and hospitalisation. We investigated the impact of serious adverse events on the risk of stroke in patients with rheumatoid arthritis (RA), taking risk factors and treatment into account.

Methods

Using data of the German biologics register RABBIT (Rheumatoid Arthritis: Observation of Biologic Therapy) with 12354 patients with RA, incidence rates (IRs) and risk factors for stroke were investigated using multi-state and Cox proportional hazard models. In addition, in a nested case-control study, all patients with stroke were matched 1:2 to patients with identical baseline risk profile and analysed using a shared frailty model.

Results

During follow-up, 166 strokes we

SUBMITTER: Meissner Y 

PROVIDER: S-EPMC5561376 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature