Optical and Magnetic Resonance Imaging Using Fluorous Colloidal Nanoparticles.

ABSTRACT: Improved imaging of cancerous tissue has the potential to aid prognosis and improve patient outcome through longitudinal imaging of treatment response and disease progression. While nuclear imaging has made headway in cancer imaging, fluorinated tracers that enable magnetic resonance imaging (¹⁹F MRI) hold promise, particularly for repeated imaging sessions because nonionizing radiation is used. Fluorine MRI detects molecular signatures by imaging a fluorinated tracer and takes advantage of the spatial and anatomical resolution afforded by MRI. This manuscript describes a fluorous polymeric nanoparticle that is capable of ¹⁹F MR imaging and fluorescent tracking for in vitro and in vivo monitoring of immune cells and cancerous tissue. The fluorous particle is derived f

SUBMITTER: Wallat JD 

PROVIDER: S-EPMC5561414 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature