Genetic Associations with Gestational Duration and Spontaneous Preterm Birth.

ABSTRACT:

Background

Despite evidence that genetic factors contribute to the duration of gestation and the risk of preterm birth, robust associations with genetic variants have not been identified. We used large data sets that included the gestational duration to determine possible genetic associations.

Methods

We performed a genomewide association study in a discovery set of samples obtained from 43,568 women of European ancestry using gestational duration as a continuous trait and term or preterm (<37 weeks) birth as a dichotomous outcome. We used samples from three Nordic data sets (involving a total of 8643 women) to test for replication of genomic loci that had significant genomewide association (P<5.0×10^-8) or an association with suggestive significance (P<1.0×10

SUBMITTER: Zhang G 

PROVIDER: S-EPMC5561422 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature