Maternal Use of Opioids During Pregnancy and Congenital Malformations: A Systematic Review.

ABSTRACT:

Context

Opioid use and abuse have increased dramatically in recent years, particularly among women.

Objectives

We conducted a systematic review to evaluate the association between prenatal opioid use and congenital malformations.

Data sources

We searched Medline and Embase for studies published from 1946 to 2016 and reviewed reference lists to identify additional relevant studies.

Study selection

We included studies that were full-text journal articles and reported the results of original epidemiologic research on prenatal opioid exposure and congenital malformations. We assessed study eligibility in multiple phases using a standardized, duplicate review process.

Data extraction

Data on study characteristics, opioid exposure, timing of exposure during pr

SUBMITTER: Lind JN 

PROVIDER: S-EPMC5561453 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature