Improving the detection sensitivity of pH-weighted amide proton transfer MRI in acute stroke patients using extrapolated semisolid magnetization transfer reference signals.

ABSTRACT:

Purpose

To quantify amide protein transfer (APT) effects in acidic ischemic lesions and assess the spatial-temporal relationship among diffusion, perfusion, and pH deficits in acute stroke patients.

Methods

Thirty acute stroke patients were scanned at 3 T. Quantitative APT (APT^# ) effects in acidic ischemic lesions were measured using an extrapolated semisolid magnetization transfer reference signal technique and compared with commonly used MTR_asym (3.5ppm) or APT-weighted parameters.

Results

The APT^# images showed clear pH deficits in the ischemic lesion, whereas the MTR_asym (3.5ppm) signals were slightly hypointense. The APT^# contrast between acidic ischemic lesions and normal tissue in acute stroke patients was

SUBMITTER: Heo HY 

PROVIDER: S-EPMC5561454 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature