Overnight delivery of hypertonic saline by nasal cannula aerosol for cystic fibrosis.

ABSTRACT:

Aim

Inhaled hypertonic saline increases mucociliary clearance, improves pulmonary function, and decreases exacerbations in cystic fibrosis (CF) but contributes to the already significant treatment burden of CF. Overnight delivery of inhaled medications via a specially designed nasal cannula-aerosol device (Trans-nasal Pulmonary Aerosol Delivery [tPAD]) is an alternative approach. Here, we test whether overnight inhalation of hypertonic saline via tPAD improves mucociliary clearance and assess the tolerability of the device.

Method

In this study, 12 CF subjects inhaled 7% hypertonic saline (HS) for 8 h overnight using the tPAD system. Safety and tolerability were assessed and measurements of mucociliary and absorptive clearance (MCC/ABS) were performed after the treatment. Co

SUBMITTER: Corcoran TE 

PROVIDER: S-EPMC5561478 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature