Pulmonary function and outcomes in infants randomized to a rescue course of antenatal steroids.

ABSTRACT:

Background/objective

Our objective was to obtain follow-up pulmonary function testing and assessment of clinical respiratory outcomes, at 1-2 years, in preterm infants whose mothers were randomized to a single rescue course of antenatal steroids (AS) versus placebo.

Methods

Follow-up of a randomized, double-blinded trial. In the original trial pregnant women ≥14 days after initial course of AS were randomized to rescue AS or placebo. Pulmonary function testing and a standardized respiratory questionnaire were obtained at 1-2 years of corrected age. Respiratory compliance (Crs) was measured with the single-breath occlusion and functional residual capacity (FRC) with the nitrogen washout method. Analysis was by intention-to-treat.

Results

A total of 96 (87%) of availabl

SUBMITTER: McEvoy C 

PROVIDER: S-EPMC5561489 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature