Predicting IDH mutation status in grade II gliomas using amide proton transfer-weighted (APTw) MRI.

ABSTRACT:

Purpose

To assess the amide proton transfer-weighted (APTw) MRI features of isocitrate dehydrogenase (IDH)-wildtype and IDH-mutant grade II gliomas and to test the hypothesis that the APTw signal is a surrogate imaging marker for identifying IDH mutation status preoperatively.

Methods

Twenty-seven patients with pathologically confirmed low-grade glioma, who were previously scanned at 3T, were retrospectively analyzed. The Mann-Whitney test was used to evaluate relationships between APTw intensities for IDH-mutant and IDH-wildtype groups, and receiver operator characteristic (ROC) analysis was used to assess the diagnostic performance of APTw.

Results

Based on histopathology and molecular analysis, seven cases were diagnosed as IDH-wildtype grade II gliomas and 20 case

SUBMITTER: Jiang S 

PROVIDER: S-EPMC5561497 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature