The impact of methylation quantitative trait loci (mQTLs) on active smoking-related DNA methylation changes.

ABSTRACT:

Background

Methylation quantitative trait loci (mQTLs) are the genetic variants that may affect the DNA methylation patterns of CpG sites. However, their roles in influencing the disturbances of smoking-related epigenetic changes have not been well established. This study was conducted to address whether mQTLs exist in the vicinity of smoking-related CpG sites (± 50 kb) and to examine their associations with smoking exposure and all-cause mortality in older adults.

Results

We obtained DNA methylation profiles in whole blood samples by Illumina Infinium Human Methylation 450 BeadChip array of two independent subsamples of the ESTHER study (discovery set, n = 581; validation set, n = 368) and their corresponding genotyping data using the Illumina Infinium OncoArr

SUBMITTER: Gao X 

PROVIDER: S-EPMC5561570 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature