Case report: value of gene expression profiling in the diagnosis of atypical neuroblastoma.

ABSTRACT:

Background

Nephroblastoma and neuroblastoma belong to the most common abdominal malignancies in childhood. Similarities in the initial presentation may provide difficulties in distinguishing between these two entities, especially if unusual variations to prevalent patterns of disease manifestation occur. Because of the risk of tumor rupture, European protocols do not require biopsy for diagnosis, which leads to misdiagnosis in some cases.

Case presentation

We report on a 4½-year-old girl with a renal tumor displaying radiological and laboratory characteristics supporting the diagnosis of nephroblastoma. Imaging studies showed tumor extension into the inferior vena cava and bilateral lung metastases while urine catecholamines and MIBG-scintigraphy were negative. Preoperative

SUBMITTER: Harttrampf AC 

PROVIDER: S-EPMC5561630 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature