Hepatoprotective and antioxidant effects of single clove garlic against CCl₄-induced hepatic damage in rabbits.

ABSTRACT:

Background

The increase in demand and consumption of single clove garlic or 'Solo garlic' (Allium sativum) has resulted in an increase in research on its therapeutic properties. The present study aims to evaluate the antioxidant activities, oxidant-scavenging efficiency and preventive effects of SCG (single clove garlic) and MCG (multi clove garlic) on CCl₄-induced acute hepatotoxicity in male rabbits.

Methods

For this purpose, rabbits were orally administered with 3 ml of CCl₄ /kg of body weight, followed by 0.8 g of MCG or SCG/kg twice a week for three successive weeks. Oxidative hepatotoxicity was then assessed.

Results

SCG extracts exhibited higher antioxidant capacity than the MCG extract. Scavenging ability of SCG showed significant (p < 0.

SUBMITTER: Naji KM 

PROVIDER: S-EPMC5561638 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature