Genetically contextual effects of smoking on genome wide DNA methylation.

ABSTRACT: Smoking is the leading cause of death in the United States. It exerts its effects by increasing susceptibility to a variety of complex disorders among those who smoke, and if pregnant, to their unborn children. In prior efforts to understand the epigenetic mechanisms through which this increased vulnerability is conveyed, a number of investigators have conducted genome wide methylation analyses. Unfortunately, secondary to methodological limitations, these studies were unable to examine methylation in gene regions with significant amounts of genetic variation. Using genome wide genetic and epigenetic data from the Framingham Heart Study, we re-examined the relationship of smoking status to genome wide methylation status. When only methylation status is considered, smoking was significantly

SUBMITTER: Dogan MV 

PROVIDER: S-EPMC5561723 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature