β-Strand mimics based on tetrahydropyridazinedione (tpd) peptide stitching.

ABSTRACT: Short peptides featuring a tetrahydropyridazinedione (tpd) backbone tether exhibit reduced conformational flexibility external to the heterocyclic constraint. Analysis by NMR, molecular modeling and X-ray crystallography suggests both covalent and non-covalent stabilization of extended peptide conformations. An efficient solid-phase protocol was developed for the synthesis of a new class of β-strand mimics based on oligomeric tpd subunits.

SUBMITTER: Kang CW 

PROVIDER: S-EPMC5561724 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature