Bottom-up assembly of salivary gland microtissues for assessing myoepithelial cell function.

ABSTRACT: Myoepithelial cells are flat, stellate cells present in exocrine tissues including the salivary glands. While myoepithelial cells have been studied extensively in mammary and lacrimal gland tissues, less is known of the function of myoepithelial cells derived from human salivary glands. Several groups have isolated tumorigenic myoepithelial cells from cancer specimens, however, only one report has demonstrated isolation of normal human salivary myoepithelial cells needed for use in salivary gland tissue engineering applications. Establishing a functional organoid model consisting of myoepithelial and secretory acinar cells is therefore necessary for understanding the coordinated action of these two cell types in unidirectional fluid secretion. Here, we developed a bottom-up approach for ge

SUBMITTER: Ozdemir T 

PROVIDER: S-EPMC5561745 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature