Revisiting the Logan plot to account for non-negligible blood volume in brain tissue.

ABSTRACT:

Background

Reference tissue-based quantification of brain PET data does not typically include correction for signal originating from blood vessels, which is known to result in biased outcome measures. The bias extent depends on the amount of radioactivity in the blood vessels. In this study, we seek to revisit the well-established Logan plot and derive alternative formulations that provide estimation of distribution volume ratios (DVRs) that are corrected for the signal originating from the vasculature.

Results

New expressions for the Logan plot based on arterial input function and reference tissue were derived, which included explicit terms for whole blood radioactivity. The new methods were evaluated using PET data acquired using [¹¹C]raclopride and [¹⁸

SUBMITTER: Schain M 

PROVIDER: S-EPMC5561763 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature