Impaired calcium sensing distinguishes primary hyperparathyroidism (PHPT) patients with low bone mineral density.

ABSTRACT:

Context

A subset of PHPT patients exhibit a more severe disease phenotype characterized by bone loss, fractures, recurrent nephrolithiasis, and other dysfunctions, but the underlying reasons for this disparity in clinical presentation remain unknown.

Objective

We sought to identify new mechanistic indices that could inform more personalized management of PHPT.

Design

Pre-, peri-, and postoperative data and demographic, clinical, and pathological information from patients undergoing parathyroidectomy for PHPT were collected. Univariate and partial Spearman correlation was used to estimate the association of parathyroid tumor calcium sensing capacity with select variables.

Patients or other participants

An unselected series of 237 patients aged >18years and under

SUBMITTER: Weber TJ 

PROVIDER: S-EPMC5561769 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature