Affective traits and history of depression are related to ventral striatum connectivity.

ABSTRACT:

Introduction

Studying remitted Major Depressive Disorder (rMDD) facilitates a better understanding of neural mechanisms for risk, given that confounding effects of active symptoms are removed. Disrupted functional connectivity has been reported in multiple networks in MDD. However, no study to date of rMDD has specifically examined connectivity of the ventral striatum (VS), a region highly implicated in reward and motivation. We investigated functional connectivity of the VS in individuals with and without a history of MDD, and in relation to affective personality traits.

Methods

Forty-two individuals with rMDD and 28 healthy controls across two sites completed resting-state fMRI and the Behavioral Inhibition System/Behavioral Activation System Scale. Voxel-wise, whole-brain

SUBMITTER: DelDonno SR 

PROVIDER: S-EPMC5562158 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature