Advanced Gene Manipulation Methods for Stem Cell Theranostics.

ABSTRACT: In the field of tissue engineering, autologous cell sources are ideal to prevent adverse immune responses; however, stable and reliable cell sources are limited. To acquire more reliable cell sources, the harvesting and differentiation of stem cells from patients is becoming more and more common. To this end, the need to control the fate of these stem cells before transplantation for therapeutic purposes is urgent. Since transcription factors orchestrate all of the gene activities inside of a cell, researchers have developed engineered and synthetic transcription factors to precisely control the fate of stem cells allowing for safer and more effective cell sources. Engineered transcription factors, mutant fusion proteins of naturally occurring proteins, comprise the three main domains of n

SUBMITTER: Rathnam C 

PROVIDER: S-EPMC5562215 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature