Cigarette smoking and telomere length: A systematic review of 84 studies and meta-analysis.

ABSTRACT:

Background

Cigarette smoking is a risk factor for ageing-related disease, but its association with biological ageing, indicated by telomere length, is unclear.

Methods

We systematically reviewed evidence evaluating association between smoking status and telomere length. Searches were performed in MEDLINE (Ovid) and EMBASE (Ovid) databases, combining variation of keywords "smoking" and "telomere". Data was extracted for study characteristics and estimates for association between smoking and telomere length. Quality of studies was assessed with a risk of bias score, and publication bias was assessed with a funnel plot. I² test was used to observe heterogeneity. Meta-analysis was carried out to compare mean difference in telomere length by smoking status, and a dose-

SUBMITTER: Astuti Y 

PROVIDER: S-EPMC5562268 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature