Inspiration from heart development: Biomimetic development of functional human cardiac organoids.

ABSTRACT: Recent progress in human organoids has provided 3D tissue systems to model human development, diseases, as well as develop cell delivery systems for regenerative therapies. While direct differentiation of human embryoid bodies holds great promise for cardiac organoid production, intramyocardial cell organization during heart development provides biological foundation to fabricate human cardiac organoids with defined cell types. Inspired by the intramyocardial organization events in coronary vasculogenesis, where a diverse, yet defined, mixture of cardiac cell types self-organizes into functional myocardium in the absence of blood flow, we have developed a defined method to produce scaffold-free human cardiac organoids that structurally and functionally resembled the lumenized vascular netw

SUBMITTER: Richards DJ 

PROVIDER: S-EPMC5562398 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature