Genomic epidemiology of a national outbreak of post-surgical Mycobacterium abscessus wound infections in Brazil.

ABSTRACT: An epidemic of post-surgical wound infections, caused by a non-tuberculous mycobacterium, has been on-going in Brazil. It has been unclear whether one or multiple lineages are responsible and whether their wide geographical distribution across Brazil is due to spread from a single point source or is the result of human-mediated transmission. 188 isolates, collected from nine Brazilian states, were whole genome sequenced and analysed using phylogenetic and comparative genomic approaches. The isolates from Brazil formed a single clade, which was estimated to have emerged in 2003. We observed temporal and geographic structure within the lineage that enabled us to infer the movement of sub-lineages across Brazil. The genome size of the Brazilian lineage was reduced relative to most strains in

SUBMITTER: Everall I 

PROVIDER: S-EPMC5562415 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature