Antiviral properties of resveratrol against pseudorabies virus are associated with the inhibition of IκB kinase activation.

ABSTRACT: Pseudorabies virus (PRV) is a pathogen of swine resulting in devastating disease and economic losses worldwide. Resveratrol (Res) exhibits inhibitory activity against a wide range of viruses. Despite these important advances, the molecular mechanism(s) by which Res exerts its broad biological effects have not yet been elucidated. In this paper, the antiviral activity of Res against PRV and its mechanism of action were investigated. The results showed that Res potently inhibited PRV replication in a dose-dependent manner, with a 50% inhibition concentration of 17.17 μM. The inhibition of virus multiplication in the presence of Res was not attributed to direct inactivation or inhibition of viral entry into the host cells but to the inhibition of viral multiplication in host cells. Further st

SUBMITTER: Zhao X 

PROVIDER: S-EPMC5562710 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature