Study on inter-ethnic human differences in bioactivation and detoxification of estragole using physiologically based kinetic modeling.

ABSTRACT: Considering the rapid developments in food safety in the past decade in China, it is of importance to obtain insight into what extent safety and risk assessments of chemicals performed for the Caucasian population apply to the Chinese population. The aim of the present study was to determine physiologically based kinetic (PBK) modeling-based predictions for differences between Chinese and Caucasians in terms of metabolic bioactivation and detoxification of the food-borne genotoxic carcinogen estragole. The PBK models were defined based on kinetic constants for hepatic metabolism derived from in vitro incubations using liver fractions of the two ethnic groups, and used to evaluate the inter-ethnic differences in metabolic activation and detoxification of estragole. The models predicted that

SUBMITTER: Ning J 

PROVIDER: S-EPMC5562778 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature