Dietary factors and polymorphisms in vitamin D metabolism genes: the risk and prognosis of colorectal cancer in northeast China.

ABSTRACT: CYP24A1 and CYP27B1 are critical genes determining 1α,25(OH)₂D₃ concentration and impacting on carcinogenesis. A case-control study including 528 colorectal cancer (CRC) patients and 605 cancer-free controls and a follow-up study with 317 cases were conducted in northeast China. Genotypes were tested by TaqMan Genotyping Assays. Individuals carrying the GG genotype of CYP27B1 G > T (rs10877012) exhibited decreased CRC risk compared with those with the TT genotype (OR_adjusted (OR_adj) = 0.57, 95% Confidence Interval (CI) = 0.38-0.84). Compared with the TT genotype, a significant association between the CC genotype of CYP27B1 C > T (rs4646536) and a reduced risk of CRC was observed (OR_adj = 0.59, 95% CI = 0.40-0.88). We also observed sign

SUBMITTER: Gong C 

PROVIDER: S-EPMC5562792 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature