Invasive trophoblast promote stromal fibroblast decidualization via Profilin 1 and ALOX5.

ABSTRACT: During the establishment of pregnancy, extravillous trophoblast (EVT) must invade into the uterine decidua to facilitate decidual artery remodelling to create the placental blood supply. The local decidual environment is thought to regulate trophoblast invasion, however these interactions are poorly defined in humans. Recent evidence in women suggests impaired decidualization is associated with miscarriage and preeclampsia. Primary human endometrial stromal cells (HESC) and first trimester extravillous trophoblast (EVTs) were used to assess the effect of EVT-secreted factors on HESC decidualization, adhesion, proliferation and migration. We determined the role of profilin (PFN)1, an EVT-secreted factor, on HESC function and identified a downstream target of PFN1. EVT-secreted factors induc

SUBMITTER: Menkhorst EM 

PROVIDER: S-EPMC5562808 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature