Thermal acclimation mitigates cold-induced paracellular leak from the Drosophila gut.

ABSTRACT: Chill susceptible insects suffer tissue damage and die at low temperatures. The mechanisms that cause chilling injury are not well understood but a growing body of evidence suggests that a cold-induced loss of ion and water homeostasis leads to hemolymph hyperkalemia that depolarizes cells, leading to cell death. The apparent root of this cascade is the net leak of osmolytes down their concentration gradients in the cold. Many insects, however, are capable of adjusting their thermal physiology, and cold-acclimated Drosophila can maintain homeostasis and avoid injury better than warm-acclimated flies. Here, we test whether chilling causes a loss of epithelial barrier function in female adult Drosophila, and provide the first evidence of cold-induced epithelial barrier failure in an inverteb

SUBMITTER: MacMillan HA 

PROVIDER: S-EPMC5562827 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature