Stability in metabolic phenotypes and inferred metagenome profiles before the onset of colitis-induced inflammation.

ABSTRACT: Inflammatory bowel disease (IBD) is associated with altered microbiota composition and metabolism, but it is unclear whether these changes precede inflammation or are the result of it since current studies have mainly focused on changes after the onset of disease. We previously showed differences in mucus gut microbiota composition preceded colitis-induced inflammation and stool microbial differences only became apparent at colitis onset. In the present study, we aimed to investigate whether microbial dysbiosis was associated with differences in both predicted microbial gene content and endogenous metabolite profiles. We examined the functional potential of mucus and stool microbial communities in the mdr1a ^-/- mouse model of colitis and littermate controls using PICRUSt on 16S

SUBMITTER: Glymenaki M 

PROVIDER: S-EPMC5562868 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature