Human protein secretory pathway genes are expressed in a tissue-specific pattern to match processing demands of the secretome.

ABSTRACT: Protein secretory pathway in eukaryal cells is responsible for delivering functional secretory proteins. The dysfunction of this pathway causes a range of important human diseases from congenital disorders to cancer. Despite the piled-up knowledge on the molecular biology and biochemistry level, the tissue-specific expression of the secretory pathway genes has not been analyzed on the transcriptome level. Based on the recent RNA-sequencing studies, the largest fraction of tissue-specific transcriptome encodes for the secretome (secretory proteins). Here, the question arises that if the expression levels of the secretory pathway genes have a tissue-specific tuning. In this study, we tackled this question by performing a meta-analysis of the recently published transcriptome data on human tis

SUBMITTER: Feizi A 

PROVIDER: S-EPMC5562915 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature