Neurodegenerative and psychiatric diseases among families with amyotrophic lateral sclerosis.

ABSTRACT:

Objective

To estimate risks of neurodegenerative and psychiatric diseases among patients with amyotrophic lateral sclerosis (ALS) and their families.

Methods

We conducted a register-based nested case-control study during 1990-2013 in Sweden to assess whether patients with ALS had higher risks of other neurodegenerative and psychiatric diseases before diagnosis. We included 3,648 patients with ALS and 36,480 age-, sex-, and county of birth-matched population controls. We further conducted a follow-up study of the cases and controls to assess the risks of other neurodegenerative and psychiatric diseases after ALS diagnosis. To assess the potential contribution of familial factors, we conducted similar studies for the relatives of patients with ALS and their controls.

Result

SUBMITTER: Longinetti E 

PROVIDER: S-EPMC5562958 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature