Assessing structure and function of myelin in cervical spondylotic myelopathy: Evidence of demyelination.

ABSTRACT:

Purpose

To assess the extent of demyelination in cervical spondylotic myelopathy (CSM) using myelin water imaging (MWI) and electrophysiologic techniques.

Methods

Somatosensory evoked potentials (SSEPs) and MWI were acquired in 14 patients with CSM and 18 age-matched healthy controls. MWI was performed on a 3.0T whole body magnetic resonance scanner. Myelin water fraction (MWF) was extracted for the dorsal columns and whole cord. SSEPs and MWF were also compared with conventional MRI outcomes, including T2 signal intensity, compression ratio, maximum spinal cord compression (MSCC), and maximum canal compromise (MCC).

Results

Group analysis showed marked differences in T2 signal intensity, compression ratio, MSCC, and MCC between healthy controls and patients with CSM.

SUBMITTER: Liu H 

PROVIDER: S-EPMC5562959 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature