Cardiovascular health in young adulthood and structural brain MRI in midlife: The CARDIA study.

ABSTRACT:

Objective

To examine the association between the American Heart Association (AHA) Life's Simple 7 (LS7) metric and brain structure.

Methods

We determined cardiovascular health (CVH) according to the AHA LS7, assigning 0, 1, or 2 points for meeting poor, intermediate, or ideal criteria for the 7 components (range 0-14) at baseline (aged 18-30 years in 1985-1986) and year 25 follow-up examination for 518 participants of the Coronary Artery Risk Development in Young Adults (CARDIA) brain MRI substudy. Visit-based CVH score and average score was assessed in relation to percent of intracranial volume of normal tissue of the whole brain, gray matter, and white matter, and abnormal tissue volume of white matter at year 25 using multivariable linear, logistic, and quantile regressio

SUBMITTER: Bancks MP 

PROVIDER: S-EPMC5562970 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature