PknB remains an essential and a conserved target for drug development in susceptible and MDR strains of M. Tuberculosis.

ABSTRACT:

Background

The Mycobacterium tuberculosis (M.tb) protein kinase B (PknB) which is now proved to be essential for the growth and survival of M.tb, is a transmembrane protein with a potential to be a good drug target. However it is not known if this target remains conserved in otherwise resistant isolates from clinical origin. The present study describes the conservation analysis of sequences covering the inhibitor binding domain of PknB to assess if it remains conserved in susceptible and resistant clinical strains of mycobacteria picked from three different geographical areas of India.

Methods

A total of 116 isolates from North, South and West India were used in the study with a variable profile of their susceptibilities towards streptomycin, isoniazid, rifampicin, ethambuto

SUBMITTER: Gupta A 

PROVIDER: S-EPMC5562987 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature