Small-size recombinant adenoviral hexon protein fragments for the production of virus-type specific antibodies.

ABSTRACT:

Background

Adenoviruses are common pathogens infecting animals and humans. They are classified based on serology, or genome sequence information. These methods have limitations due to lengthy procedures or lack of infectivity data. Adenoviruses are easy to produce and amenable to genetic and biochemical modifications, which makes them a powerful tool for biological studies, and clinical gene-delivery and vaccine applications. Antibodies directed against adenoviral proteins are important diagnostic tools for virus identification in vivo and in vitro, and are used to elucidate infection mechanisms, often in combination with genomic sequencing and type specific information from hyper-variable regions of structural proteins.

Results

Here we describe a novel and readily useable m

SUBMITTER: Pacesa M 

PROVIDER: S-EPMC5563037 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature