Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolome.

ABSTRACT:

Background

Space travel is associated with continuous low dose rate exposure to high linear energy transfer (LET) radiation. Pathophysiological manifestations after low dose radiation exposure are strongly influenced by non-cytocidal radiation effects, including changes in the microbiome and host gene expression. Although the importance of the gut microbiome in the maintenance of human health is well established, little is known about the role of radiation in altering the microbiome during deep-space travel.

Results

Using a mouse model for exposure to high LET radiation, we observed substantial changes in the composition and functional potential of the gut microbiome. These were accompanied by changes in the abundance of multiple metabolites, which were related to the enzyma

SUBMITTER: Casero D 

PROVIDER: S-EPMC5563039 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature